Our analysis of predicted targets for lncRNAs changed after irradiation and chemoexposure indicated that these non-coding RNAs influence cellular processes and pathways participating in direct response to these agents such as cell cycle, apoptosis, RAS pathway, p53 pathway, as well as on factors connected with cellular phenotype and cancer initiating cells such as cadherin, Wnt, TGF-beta, EGFR, and Notch signaling pathways and also on angiogenesis. Here, TP53 is linked to cancer.