JAK2 and neoplasm: Functionally, miR-375 acts as a tumor suppressor that inhibits cell proliferation, migration, invasion, and tumor metastasis [21,28,29,33] by targeting several important oncogenes, including phosphoinositide-dependent protein kinase-1 (PDK1) [22,34], 14-3-3 protein zeta (14-3-3ζ) [22,35], Yes-associated protein (YAP) [36], astrocyte elevated gene-1 (AEG1) [28,37,38], lactate dehydrogenase B (LDHB) [39], and Janus kinase 2 (JAK2) [21].