NBN and Nijmegen breakage syndrome: Finally, as several of these OC-susceptibility genes, i.e., NBN, ATM or BRIP1, are associated with the development of autosomal recessive disorders, such as Nijmegen breakage syndrome, ataxia-teleangiectasia (MIM: 208900) or Fanconi anemia (MIM: 609054), respectively, genetic counselling for carriers of pathogenic variants in any of these genes should also include a discussion of reproductive and prenatal screening possibilities.