Different studies have shown that the plasma levels of soluble P-selectin (sP-sel), soluble CD40 ligand (sCD40L), thrombospondin-1 (TSP1) and ß-thromboglobulin were significantly higher in cancer patients than in healthy controls, strongly suggesting that platelets get activated during cancer progression [32,33,34,35,36]. The gene discussed is CD40LG; the disease is cancer.