The Ras-responsive transcription factor Ets-2 was shown to regulate UCA1 transcription in both bladder and colorectal cells [109,114], UCA1 is upregulated by the major inducer of epithelial-mesenchymal transition (EMT) TGFβ in gastric and breast cancer cells [115] and by mediators of chemoresistance like Hippo (TAZ/YAP/TEAD) signaling in bladder and breast cancer cells [116,117]. This evidence concerns the gene UCA1 and breast cancer.