Interestingly, the tumor suppressor KLF2 gene is reported to be silenced in CRC cells by several lncRNAs through this mechanism (e.g., SH3PXD2A-AS1, HOXA-AS2 [30,31]), whereas for most genes, only a unique lncRNA/EZH2 combination is known. This evidence concerns the gene EZH2 and colorectal carcinoma.