For the association between potassium ion channels variants and increased risk of epilepsy and its subtypes, Jorge et al. (2011) identified unique nonsynonymous KCNV variants R7K and M285R in two unrelated epileptic children, leading to differences in clinical variability and a potential of improving Kv8.2-mediated suppression of Kv2.1 currents [16]. Here, KCNB1 is linked to epilepsy.