Different studies demonstrated that SFN treatment could induce the time- and dose-dependent down-regulation of Janus kinase 2 (JAK2) and Src kinases phosphorylation in GBM cells via post-translational modification of cysteine residues, which can potentially inhibit the STAT3 pathway in a ROS-dependent manner [103,110]. This evidence concerns the gene JAK2 and glioblastoma.