Several authors have suggested that CSF α‐syn species might be more informative when used in combination with other biomarkers, for example, Aβ1‐42, t‐tau, and p‐tau.25, 36, 37, 49 In the present study, we demonstrated that CSF α‐syn species add discriminatory value to traditional CSF AD biomarkers. Here, MAPT is linked to Alzheimer disease.