Expression of all the 23 target genes changed in HT1080 cells (Fig 1D and S1B Fig); 20 genes were up-regulated and two genes PDGFR β and WRNIP1 were down-regulated (OPN4 did not change significantly; PDGFR β decrease on TRF2 silencing in cancer cells was also noted earlier[27]). The gene discussed is OPN4; the disease is cancer.