HOTAIR and breast cancer: As research on lncRNA function advances, a close relationship between lncRNAs and tumor development is slowly emerging.5, 6 For example, the lncRNA HOTAIR is overexpressed in breast cancers, as well as colon, pancreas, and pulmonary carcinomas, among others.8, 9, 10, 11 Moreover, high expression of HOTAIR is associated with metastasis of breast and colon cancer.12, 13, 14 Another identified lncRNA, MALAT-1, was reported to promote motility of cancer cells in patients with pulmonary adenocarcinoma.15