However, a few CDDP‐resistant cases have also reported, usually with a poor outcome.20 Several mechanisms underlying the high sensitivity or the resistance of seminoma cells to CDDP have been reported.21, 22 One of these mechanisms reported involved the TDRG1 gene, which can modulate the activity of PI3K/Akt signaling pathway to regulate CDDP sensitivity.6 In this study, we expanded our knowledge of TDRG1 in seminoma and cellular responses to CDDP. This evidence concerns the gene AKT1 and seminoma.