AFP and neoplasm: Moreover, large tumor sizes (>39 mm) were associated with many unfavorable characteristics, including regional lymph node metastases (P < 0.001), distant metastases (P < 0.001), vascular invasion (P < 0.001), elevated alpha‐fetoprotein (AFP) level (P < 0.001), and higher rate of widowed marriage status (P < 0.001).