CAMK2G and Increased circulating aldosterone concentration: 2009). Calcineurin is involved in the development of cardiac hypertrophy and fibrosis induced by mineralocorticoid excess (Takeda et al. 2002).Another negative crosstalk between these two enzymes has also been suggested dephosphorylation of CaMKII at its autophosphorylation site by calcineurin (Kubokawa et al. 2011).