In our study, to demonstrate the hypothesis that TNF‐α‐induced NPC proliferation associated with the NF‐κB pathway, we knocked down NF‐κB‐p65 with p65 siRNA and found that cells blocking the p65 pathway proliferated more slowly than the control cells did under TNF‐α stimulus. Here, NFKB1 is linked to nasopharyngeal carcinoma.