FZD4 and neoplasm: Wnt2 activates canonical Wnt signaling and upregulates β‐catenin target genes.30, 31 Wnt2 expression is associated with anchorage‐independent cell survival, tumor invasion and metastasis in cancer cells.32, 33 Hepatitis C virus core protein upregulates gene expression of canonical Wnt ligands Wnt2 in the SMMC7721 cell line.34 WNT2 messenger RNA is upregulated in colorectal polyps, primary colorectal cancer of stage A‐C, and also in liver metastasis from colorectal cancer.35 Frizzled 4 is an essential receptor in the Wnt/β‐catenin signaling.