The nuclear translocation of β‐catenin results in the activation of canonical Wnt/β‐catenin signaling, leading to the transcriptional activation of downstream targets.16 In the study, we demonstrated that knockdown of CRNDE downregulated Wnt2, Frizzled 4, and β‐catenin expression in HCC cells. This evidence concerns the gene CRNDE and hepatocellular carcinoma.