LncRNA colorectal neoplasia differentially expressed (CRNDE) is activated early in colorectal neoplasia.7 Recent reports have demonstrated that CRNDE regulates cell proliferation, apoptosis, migration, and invasion in various cancers.8, 9, 10 But the underlying mechanism of CRNDE regulating EMT in HCC is still largely unclear. Here, CRNDE is linked to hepatocellular carcinoma.