FZD4 and hepatocellular carcinoma: The nuclear translocation of β‐catenin results in the activation of canonical Wnt/β‐catenin signaling, leading to the transcriptional activation of downstream targets.16 In the study, we demonstrated that knockdown of CRNDE downregulated Wnt2, Frizzled 4, and β‐catenin expression in HCC cells.