Most recently, Volonté and colleagues have demonstrated for the first time the increased expression of P2X4 and P2X7 proteins in the peripheral nervous system of SOD1-G93A mice, namely in sciatic nerves, and nominated these P2 receptors as potential diagnostic biomarkers for ALS at the peripheral level [9]. The gene discussed is P2RX7; the disease is amyotrophic lateral sclerosis.