The authors showed that short treatment (from asymptomatic to symptomatic phase) with antihistamine drug clemastine reduced disease progression and improved survival of SOD1G93A ALS mice by enhancing anti-inflammatory phenotype of microglia via upregulation of P2Y12 together with P2Y7, arginase-1 and CD1639. This evidence concerns the gene P2RY12 and amyotrophic lateral sclerosis.