CD4 and neoplasm: We previously identified a WT1 protein-derived 16-mer HLA class II peptide, WT1332 (KRYFKLSHLQMHSRKH), which can elicit WT1332-specific CD4+ T-cell responses, and demonstrated that this WT1332 peptide was endogenously generated from the WT1 protein in WT1-expressing tumor cells.