Similar to G6PD, mRNA levels of the other two enzymes involved in the oxidative phase of the PPP, 6-phosphogluconolactonase (PGLS) and 6-phosphogluconate dehydrogenase (PGD), were higher in HCC samples compared to control tissue (Figures 2B,C). The gene discussed is G6PD; the disease is hepatocellular carcinoma.