As shown in Figure 4A, when HCC patients were divided into two groups according to the median value of each gene transcript that is HK2, PKM2, ALDOA, and LDHA we found that the overall survival rate was significantly lower in the high expression groups in the TCGA-LIHC patient cohort (P < 0.05). The gene discussed is LDHA; the disease is hepatocellular carcinoma.