LDHA and hepatocellular carcinoma: Of note is also the observation that the expression of LDHA (or LDHB) (the glycolytic enzymes converting pyruvate in lactate) have no HCC risk associated in cirrhotic patients (Figure 7), suggesting that glycolytic-derived pyruvate may not be all converted in lactate and is therefore channeled to other metabolic pathways (i.e., mevalonate pathway; discussed below).