PKM and hepatocellular carcinoma: As shown in Figure 1B, expression of the majority of glycolytic transcripts, including the rate limiting glycolytic enzyme HK2 [hexokinase 2], ALDOA [aldolase, fructose-bisphosphate A], PFKL [6-phosphofructokinase, liver type], GAPDH [glyceraldehyde 3-phosphate dehydrogenase], PKM2 [pyruvate kinase M2]) was significantly increased in HCC livers compared to their adjacent non-tumor tissues (P < 0.0001).