In glioma, Gondi et al. validated that siRNA-mediated silence of uPAR and cathepsin B (CTSB) inhibited glioma cell migration and was accompanied by cytoskeletal condensation, and the simultaneous silence of uPAR and CTSB was even more effective at inducing cytoskeletal condensation than uPAR alone (39). The gene discussed is CTSB; the disease is central nervous system cancer.