As a member of the platelet-derived growth factor, VEGF could contribute to the proliferation of vascular endothelial cells, mitogenesis, and angiogenesis, suppression of dendritic cell maturation, increase in the permeability of the blood vessels, facilitating the leakage of vascular contents and thus providing extracellular matrix for vascular formation and endothelial cell migration, which play a crucial role for the development of cancer cells (58–60). Here, VEGFA is linked to cancer.