STAT3 possesses regulatory abilities in angiogenesis through the transcription of vascular endothelial growth factor (VEGF) (9), a potent angiogenic factor which plays a crucial role in a several pathological processes including microvascular permeability, tumor cell penetration (6), acting as an important mediator of angiogenesis, representing a potential target for anticancer therapy (10). Here, VEGFA is linked to neoplasm.