SELP and neoplasm: A single dose of heparin administered shortly before the introduction of tumor cells into the bloodstream has already been found to attenuate hematogenous metastasis in mice primarily by inhibiting P-selectin.22 Upon verifying that PGMs themselves did not affect viability of tumor cells (ESI Fig. S44†), we used a similar murine model and regimen and performed bioluminescence imaging to quantify tumor burden at 2 weeks after the intravenous injection of luciferase-expressing B16-F10 Red-Fluc cells.