It was previously demonstrated that the production of PGE2 induced by flagellin injection or S. Typhimurium infection was attenuated in cells that do not express NLRC4 (von Moltke et al., 2012), which suggests that the presence of NLRC4 inflammasome is critical for the induction of PGE2 biosynthesis during infection. This evidence concerns the gene NLRC4 and infection.