In this study, we found high expression of orexin-A in advanced pancreatic cancer specimens (Figure 1) and highexpression of prepro-orexin and OX1R in pancreatic cancer cells, resulting in cell proliferation (Figure 2) and suggesting that thestimulation of OX1R might be essential for tumorigenesis in pancreatic cancer. This evidence concerns the gene HCRTR1 and pancreatic neoplasm.