Feng et al. (2014) developed VEGF-targeted siRNA- (siVEGF) and PTX-loaded vapreotide-modified core-shell type nanoparticles for improved intracellular siRNA accumulation and VEGF down-regulation in human breast cancer MCF-7 cells as compared to non-ligand nano-chemotherapeutics. This evidence concerns the gene VEGFA and breast carcinoma.