Besides this, the increased deposition of ECM in tumor microenvironment governed by various angiogenic growth factors, VEGF, stromal cell derived factor 1, Ang-2, PDGF-B, placental growth factor, and connective tissue growth factors are all associated with solid stress (Danhier et al., 2010; Muntimadugu et al., 2017). This evidence concerns the gene CXCL12 and neoplasm.