TGFB1 and neoplasm: The seminal work done by Kano et al. (2007) demonstrated TβR-I (crucial for TGF-β signaling) inhibitor mediated enhanced extravasation of Doxil® (108 nm diameter) as well as micellar adriamycin (65 nm diameter) induced by decreased pericyte coverage of tumor endothelial cells in pre-treated xenografted BxPC3 human pancreatic adenocarcinoma cell line in nude mice.