Synaptic vesicle-associated proteins are implicated in the regulation of BDNF-induced axonal growth and neurotransmitter release (Kao et al., 2017; Marte et al., 2017), and increasing evidence has demonstrated the relationship between synaptic dysfunction and depression (Duman and Aghajanian, 2012). The gene discussed is BDNF; the disease is major depressive disorder.