TNNI3 and myocardial ischemia: Irrespective of the presence of typical signs and symptoms of myocardial ischemia and suggestive electrocardiographic (ECG) abnormalities, the measurement of cardiac troponins (cTns), either cardiac troponin I (cTnI) or cardiac troponin T (cTnT), has become the culprit of making a specific clinical decision, particularly for diagnosing non-ST elevation myocardial infarction (NSTEMI) (3, 4).