The addition of polyclonal human antibodies to the culture system dose-dependently enhanced T cell activation as compared with antibody alone, (Fig. 4b) and mediated a complete lysis of melanoma cells in the context of the high-affinity receptors CD16 VH- and CD16 VL-CAR-T cells (Fig. 4c). The gene discussed is FCGR3A; the disease is melanoma.