Further, in IBS patients and healthy subjects the Bacteroides enterotype (n = 15) had higher fecal protein levels of granins (CgA, CgB, SgII and SgIII) but lower bacterial alpha diversity compared to the Clostridiales (n = 59) and Prevotella enterotype (n = 8, Fig. 5b,c). This evidence concerns the gene CHGB and irritable bowel syndrome.