In both IBS patients and healthy subjects the protein levels of fecal CgA, CgB, SgII and SgIII and mucosal mRNA expression of CgA, CgB and SgIII were highly correlated with each other, while the mucosal mRNA expression of SgII did not correlate with the other mucosal granins (Supplementary Table 2). The gene discussed is CHGB; the disease is irritable bowel syndrome.