TERC and cancer: Newly implicated here in nevogenesis, TERC is a strong candidate given its involvement in telomere maintenance and prior suggestive evidence of association with melanoma/nevi10,14,15, as well as several other cancers.16–18PPARGC1B has previously been investigated as a skin color locus17 and there is functional evidence for its effects on melanocytes.18GPRC5A (see Fig. 4a, Supplementary Fig. 15) has also been suggestively associated with melanoma10 and is a known oncogene in breast and lung cancer19,20.