LRP5 and colorectal cancer: Mutations in AC010091.1 were mutually exclusive to TCF7L2 and KRAS. Our data also suggest that LRP1B, a negative regulator of Wnt signaling that is downregulated in right-sided colorectal cancer (rCRC)29, may play a role in Wnt signaling upstream of APC, as an alternative to the TCGA’s proposed LRP5. LRP1B mutations were nearly always associated with triploidy.