Of these 48 genes, 12 were present in the matrisome of metastatic CRC tumor samples of which 11 had lower protein abundance in the metastasis samples32, including ADAMTSL1, which was a colon tumor-specific extracellular matrix (ECM) protein, not present in normal colon, metastasis nor liver tissue. The gene discussed is ADAMTSL1; the disease is colonic neoplasm.