TRPV3 and Olmsted syndrome: Activation of TRPV3 in keratinocytes has been shown to lead to release of proinflammatory messengers, and several “gain-of-function” mutations in trpv3 have been found to cause the human congenital skin disorder Olmsted syndrome, characterized by bilateral mutilating palmoplantar keratoderma, periorificial keratotic plaques, and hair loss with follicular papules15–22.