Notably, the gain-of-function mutations that cause Olmsted syndrome are located in the S4−S5 linker and its junctions with the S4b, S3, the TRP domain, and the lower part of S6, underscoring the importance of the S4–S5 linker in TRPV3 channel gating (Supplementary Fig. 6). The gene discussed is TRPV3; the disease is Olmsted syndrome 1.