ERBB2 and breast cancer: The observations revealed that the combination was more effective in inhibiting the capability of trans-endothelium than that of trastuzumab alone for HER2+ BC cells (Control: 167 ± 10 cells, trastuzumab: 109 ± 25 cells, YHD + trastuzumab: 50 ± 6 cells, P=0.016).