DRC4 and neoplasm: GAS8 antisense RNA 1 (GAS8-AS1), which is located in the second intron of GAS8 and transcribes a 994-nt lncRNA in the opposite orientation of GAS8, has been reported to be a novel tumor suppressor that can affect tumor cell proliferation in PTC [13], but the mechanism of how GAS8-AS1 regulates tumor cell function remains unclear.