To obtain a comprehensive estimate of the putative influence of the genetic polymorphisms of these genes on CRC risk, XPD G751A, hOGG1 C326G and XRCC4 G1394T polymorphisms in CRC patients were detected in this case–control study in a sample of the Chinese population with the aim of providing a theoretical basis for the treatment and prognosis of the disease. The gene discussed is XRCC4; the disease is colorectal carcinoma.