Interestingly, individuals carrying the XPD locus A allele and OGG1 locus G allele showed an increased CRC risk (OR = 1.85, 95%CI = 1.331–2.584, P<0.001; adjusted OR = 1.543, 95%CI = 1.302–2.542, P=0.002). This evidence concerns the gene ERCC2 and colorectal carcinoma.