Similarly, the combined effect of the hOGG1 locus G allele and the XRCC4 locus T allele was to increase susceptibility to CRC development (OR = 2.461, 95%CI = 1.826–3.317, P<0.001; adjusted OR = 3.854, 95%CI = 1.924–7.123, P<0.001). This evidence concerns the gene XRCC4 and colorectal carcinoma.