Because TEX101 levels were found significantly lower in heterozygous and homozygous men, rs35033974 status may be considered in the clinical use of TEX101 protein as a biomarker of male infertility (to evaluate vasectomy success, differentiate between nonobstructive and obstructive azoospermia, and predict the success of sperm retrieval in patients with non-obstructive azoospermia) (8). This evidence concerns the gene TEX101 and male infertility.