UGT1A1 and cancer: It is possible to hypothesize that cancer patients concurrently infected with T. gondii, if administered irinotecan, may experience serious toxicity due to limited detoxification and increased accumulation of SN-38 caused by reduced expression of UGT1A. The expression of UGT1A during the T. gondii-host interaction raises a new question about the potential impact of parasite infection on irinotecan-treated cancer patients.