PTH and hypercalcemia disease: PHPT was the first clinical manifestation in 92 cases (63.45% of all MEN1 affected patients; 66.19% of PHPT cases); 25 of them were diagnosed with PHPT after symptoms of nephrocalcinosis and/or renal colic, while 67 were biochemically diagnosed in presence of elevated serum PTH and, in the great majority of cases (65), also hypercalcemia.