Indeed, data from our database highlighted that all the precociously deceased patients were characterised by a late diagnosis of MEN1 (about 15 years after the occurrence of the first clinical manifestation), and they were already presenting, at the time of diagnosis, malignancies (with or without metastasis) and/or severe tumour-related consequences untreatable by current available surgical and/or medical options. Here, MEN1 is linked to neoplasm.