Transphenoidal resection of pituitary adenomas was performed in 11 patients (14.67% of pituitary tumour-affected patients): 2 were ACTH-secreting tumours, 1 was a GH-secreting tumour, 2 were non-secreting adenomas and 6 were macro-PRLomas whose PRL over-secretion could not be controlled by pharmacological therapy. This evidence concerns the gene POMC and neoplasm.