Univariate and multivariate Cox regression analyses indicated that higher ages, pathologic T stage and elevated creatinine levels after surgery were unfavorable prognostic factors in ccRCC patients, except for high protein expression of CLDN7, which was a favorable prognostic factor (HR = 0.227, 95% CI = 0.093–0.551, p = 0.001) (Table 2). Here, CLDN7 is linked to nonpapillary renal cell carcinoma.