NANOG and neoplasm: Also in BCa, a link between hypoxia, tumor invasiveness/metastasis and m6A has been proposed, with hypoxia-inducible factors (HIFs) leading to increased mRNA expression of the pluripotency factor homeobox transcription factor Nanog (NANOG) (and subsequent BCa stem cells specification) by means of m6A demethylation by the eraser ALKBH5 [52,53].