Pancreatic cancer cells and PSCs produce Treg cell attractants CXCL10, CCL3, CCL4, CCL5, and vascular endothelial growth factor (VEGF) and interact with Treg cell-surface receptors CXCR3, CCR5, and neuropilin-1 to promote Treg cell migration and infiltration [38,39,40,41,42]. Here, VEGFA is linked to familial pancreatic carcinoma.