These new features need to be incorporated into future trial design, and indeed several trials are including a retrospective or prospective analysis of potential companion biomarkers (including tumour RB expression by immunohistochemistry plus CDK4/6 amplification or CCND1 amplification) as part of the clinical assessment of PD-0332991 efficacy in PDAC (The MATCH Screening Trial NCT02465060, NCT02501902). Here, CDK4 is linked to neoplasm.