Comprehensive preclinical exploration of the long-term responsiveness to CDK4/6 inhibition and CDK4/6 inhibitor-based combinations, highlights the need for a more personalised approach in the treatment of pancreatic cancer, with RB as a potential companion biomarker that may help enrich for responders to CDK4/6 inhibitor-regimens [78]. Here, CDK4 is linked to familial pancreatic carcinoma.