NPM1 and acute myeloid leukemia: Both Kaplan-Meier and univariate/multivariate analyses showed that favorable FLT3/NPM1 combination (FLT3−/NPM1+) had better prognosis than the rest of FLT3/NPM1 combinations (FLT3+/NPM1−, FLT3−/NPM1− and FLT3+/NPM1+) regarding OS, DFS and CIR (Table 1, Table 2 and Table S2); therefore, being FLT3−/NPM1+ identified as an independent favorable prognostic factor in our IR-AML cohort.