We identified PTK2B or LYN overexpression as independent favorable prognostic factors for OS, DFS and CIR in the cytogenetic IR-AML patients bearing the different non-favorable FLT3/NPM1 combinations (FLT3+/NPM1−, FLT3−/NPM1−, FLT3+/NPM1+). Here, PTK2B is linked to acute myeloid leukemia.