Furthermore, a DNA aptamer targeting human PD-L1 (aptPD-L1) was able to block the binding between human PD-1 and PD-L1 and helped T cell function restoration, modified TME and inhibited tumor growth in CT26 colorectal cancer and LL/2 lung cancer murine syngeneic tumor models [121]. The gene discussed is CD274; the disease is lung carcinoma.