Accordingly, the anti-PDGFRβ 2′F-Py-RNA Gint4.T aptamer was able to target PDGFRβ-positive GBM either subcutaneously or intracranially implanted in mice, acting as inhibitor of tumor growth [42] and delivery agent for drug-loaded nanoparticles [63]. This evidence concerns the gene PDGFRB and glioblastoma.