Since whole-blood transcriptome profiling has been proposed as a reliable measure of immune responses in TB patients (Berry et al., 2010), and because the plasma levels of HO-1 have been suggested as a potential TB diagnostic marker (Andrade et al., 2013, Andrade et al., 2014), we generated global transcriptomic profiles of blood monocytes from Mtb-infected mice. The gene discussed is HMOX1; the disease is tuberculosis.