Enhanced Hdac4 expression has been reported after sciatic nerve transection, and in neurogenic muscle atrophy mouse models of ALS and NMD (Neuromuscular degeneration) [12], and upregulation of Hdac4 is associated with faster functional muscle decline and lower muscle re-innervation ability in ALS patients [74]. This evidence concerns the gene HDAC4 and Skeletal muscle atrophy.