Previous research using the Redin-SCORE, which predicts the risk of re-hospitalization for worsening heart failure, shows that the presence of Framingham left HF signs, eGFR <60 mL/min/m2, BNP >43 pmol/L (>150 ng/L) or NT-pro BNP >118 pmol/L (>1000 ng/L), heart rate >70 bpm, the presence of anemia, and a left atrial size >26 mm/m2 are risk factors for re-hospitalization for worsening heart failure [21]. This evidence concerns the gene NPPB and heart failure.