In RKO CRC cell line, treatment with C, P, PE, NI, IPI and the combination of C+PE, P+NI, P+PE, P+IPI induced autophagy as it measured through the increasing ratio of LC3II/I (1.2 to 2.2 folds) and the reduction of p62 (0.2 to 0.7 folds). Here, SQSTM1 is linked to colorectal carcinoma.