The ratio of LC3II/LC3I remained increased in comparison with untreated cells (1.1 to 1.5 folds) after treatment with PD (Fig 7B). These data identified the ERK-depended mechanism of autophagy induction and PD-L1 protein expression in MSI-H CRC cell line RKO after treatment with anti-EGFR mAbs and check point inhibitors. Here, EGFR is linked to colorectal carcinoma.