CASP3 and neoplasm: The triple inhibition A+E+PD (A+C+PD, A+P+PD) and A+PD+I (A+PD+NI, A+PD+PE, A+PD+IPI) triggered strong apoptotic cell death as it was identified through cleaved caspase-3 and apoptotic nuclei and a significant reduction of tumor mass in 3D culture (Fig 6B and 6C).