OGFOD1 and Pallister-Hall syndrome: The available biophysical evidence, principally from crystallography, implies that key features in the active sites of the different types of human PHs are substantially, but not completely, conserved.4 Therefore, there is the potential that inhibitors targeting OGFOD1 could also interfere with hypoxia sensing and collagen biosynthesis through inhibition of other PHs (or vice versa).