5,11 Studies have been suggesting an elevated s-IgA level is associated with a lower risk of developing gingivitis; 12 however, studies on this association in children remain scarce. In addition, studies have shown chronic stress promotes a decrease in s-IgA in children. 13 Therefore, s-IgA is an important biomarker of immune imbalances in children and may be related to oral disease development. The gene discussed is CD79A; the disease is mouth disorder.