ACHE and Alzheimer disease: Considering that inhibition of PARP-1 has therapeutical values not only for cancer but also for AD, a series of 15 novel Olaparib analogues was synthesized, and their inhibitory activities against the enzymes PARP-1, AChE (from electric eel), BChE (from equine serum) and the cancer cell line MDA-MB-436 were tested.